About Us

PALUPA Medical Ltd. is a Startup built by three Scientists (Dr. Marios Pantzaris, Mr George Loukaides and Dr. Ioannis Patrikios), with the support of Helix Business Incubator, a high tech and innovation incubator.

The company was founded in 2006 and the initial goal was to design, plan, and execute a pioneer and innovative research program for the treatment of Multiple Sclerosis (MS) by investigating the safety and therapeutic effect of a nutritional-drug formulation (nutraceutical) for the disease. During the initial period, the company got involved in designing and executing all components of the Drug Development Process such as:

  • Application and approval by the Cyprus National Bioethics committee to perform clinical studies on Humans
  • Design and execution of Clinical Trials
  • Evaluation of Results
  • Final Reports
  • Patent application with the US Patent and a PCT

The company continued its activities as a research and innovation company and completed another 4 clinical studies, including a Phase III study (the MINERAL STUDY) both for Parkinson’s and Multiple Sclerosis.

1

Pantzaris MC, Bakirtzis C, Grigoriadis N, Hadjigeorgiou G, Dardiotis E, Loucaides G, Ntzani E, Markozannes G, Omorfos S, Valsasina P, Messina R, Preziosa P, Rocca MA, Patrikios I. Phase III, randomised, double-blind, placebo-controlled trial of Neuroaspis plp10 as an adjuvant treatment for relapsing multiple sclerosis: the MINERAL Study. BMJ Neurol Open. 2022 Nov 4;4(2):e000334. doi: 10.1136/bmjno-2022-000334. PMID: 36353267; PMCID: PMC9639060.

2

Marios C. Pantzaris, George N. Loukaides, Evangelia E. Ntzani & Ioannis S. Patrikios. A novel oral nutraceutical formula of omega-3 and omega-6 fatty acids 2with vitamins (PLP10) in relapsing remitting multiple sclerosis: a randomised, double-blind, placebo-controlled proof-of-concept clinical trial. BMJ Open 2013; 3:e002170.doi:10.1136/bmjopen-2012-00217

3

Pantzaris M, Loukaides G, Paraskevis D, Kostaki EG, Patrikios I. Neuroaspis PLP10™, a nutritional formula rich in omega-3 and omega-6 fatty acids with antioxidant vitamins including gamma-tocopherol in early Parkinson’s disease: A randomized, double-blind, placebo-controlled trial. Clin Neurol Neurosurg. 2021 Nov;210:106954. doi: 10.1016/j.clineuro.2021.106954. Epub 2021 Sep 17. PMID: 34607196.

4

Pinelopi S. Stavrinou, Eleni Andreou, George Aphamis, Marios Pantzaris, Melina Ioannou, Ioannis S. Patrikios and Christoforos D. Giannaki; The Effects of a 6-Month High Dose Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Antioxidant Vitamins Supplementation on Cognitive Function and Functional Capacity in Older Adults with Mild Cognitive Impairment; Nutrients 2020, 12(2), 325

5

Panayiotis Aristotelous, Manos Stefanakis, Marios Pantzaris, Constantinos S. Pattichis, Philip C. Calder, Ioannis S. Patrikios, Giorgos K. Sakkas, Christoforos D. Giannaki; The Effects of Specific Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Antioxidant Vitamins on Gait and Functional Capacity Parameters in Patients with Relapsing-Remitting Multiple Sclerosis Nutrients. 2021 Oct; 13(10): 3661. Published online 2021 Oct 19. doi: 10.3390/nu13103661

Mission and Values

At PALUPA Medical Ltd., our mission is to improve the quality of life for people living with multiple sclerosis (MS) by providing a safe, effective and natural dietary supplement. We are committed to advancing scientific research and clinical trials to develop innovative treatments for chronic incurable diseases such as MS and to promote a holistic approach that integrates traditional and alternative therapies.

Our values of scientific rigor, patient-centered care, sustainability, transparency and innovation guide everything we do as we work to make a positive difference in the lives of multiple sclerosis patients around the world.

At PALUPA Medical Ltd., we are guided by a set of core values that reflect our commitment to scientific excellence and patient-centered care. We believe in the importance of rigorous scientific testing and development to ensure the safety and efficacy of our products and are dedicated to providing patient-centered care that meets the unique needs of people living with MS. We prioritize sustainability in our manufacturing and distribution practices and are committed to transparency and honesty in all of our interactions with customers and healthcare providers. Above all, we value innovation and strive to develop cutting-edge solutions to improve the lives of multiple sclerosis patients and push the boundaries of scientific research in the field of chronic diseases.

Scientific Team

Dr Ioannis Patrikios

Professor of Medical Biochemistry, Lipidologist/ Immunologist Medical School, European University of Cyprus

Dr Ioannis Patrikios is a professor and Deputy Dean at the Medical School of the European University of Cyprus and a Scientific Collaborator at the Cyprus Institute of Neurology and Genetics

Dr Marios Pantzaris

Senior Neurologist, Professor, The Cyprus School of Molecular Medicine

Dr Marios Pantzaris is a Head of Neurology Clinic C at the Cyprus Institute of Neurologist and Genetics

Dr. George Loukaides

Registered Dietician and Clinical Nutritionist

Dr Marios Pantzaris is a Head of Neurology Clinic C at the Cyprus Institute of Neurologist and Genetics